Notable Publications

Structures of LRP2 reveal a molecular machine for endocytosis

Structures of full-length native mouse LRP2 reveal that it is a homodimer that undergoes dramatic pH-dependent structural transitions that renders it ligand-receptive at the cell surface and ligand-shedding in endosomes. Beenken et al., 2023, Cell 186, 821–836

Clinical and Genetic Characteristics of CKD Patients with High-Risk APOL1 Genotypes

In this genetically matched cohort, high-risk APOL1 genotypes were associated with an increased risk of kidney failure and eGFR decline rate, with a graded risk between specific high-risk genotypes and a lower rate of monogenic kidney disease. Rare missense variants in the inflammasome pathway may act as genetic modifiers of APOL1 effect on kidney disease. Elliot et al., J Am Soc Nephrol. 2023 Feb 9.

Comprehensive Associations between Acidosis and the Skeleton in Patients with Kidney Disease

Metabolic acidosis is associated with multiple impairments in bone quality. Future work should examine whether correction of acidosis improves bone quality and strength in patients with CKD. Levy et al., J Am Soc Nehprology. April 2023

  • Elliott MD, Rasouly HM, Gharavi AG. Genetics of Kidney Disease: The Unexpected Role of Rare Disorders. Annu Rev Med. 2023 Jan 27;74:353-367. doi: 10.1146/annurev-med-042921-101813. Epub 2022 Nov 14. PMID: 36375470.
  • Verbitsky M, Krishnamurthy S, Krithivasan P, Hughes D, Khan A, Marasà M, Vena N, Khosla P, Zhang J, Lim TY, Glessner JT, Weng C, Shang N, Shen Y, Hripcsak G, Hakonarson H, Ionita-Laza I, Levy B, Kenny EE, Loos RJF, Kiryluk K, Sanna-Cherchi S, Crosslin DR, Furth S, Warady BA, Igo RP Jr, Iyengar SK, Wong CS, Parsa A, Feldman HI, Gharavi AG. Genomic Disorders in CKD across the Lifespan. J Am Soc Nephrol. 2022 Oct 27. doi: 10.1681/ASN.2022060725. Epub ahead of print. PMID: 36302597.
  • Liu L, Khan A, Sanchez-Rodriguez E, Zanoni F, Li Y, Steers N, Balderes O, Zhang J, Krithivasan P, LeDesma RA, Fischman C, Hebbring SJ, Harley JB, Moncrieffe H, Kottyan LC, Namjou-Khales B, Walunas TL, Knevel R, Raychaudhuri S, Karlson EW, Denny JC, Stanaway IB, Crosslin D, Rauen T, Floege J, Eitner F, Moldoveanu Z, Reily C, Knoppova B, Hall S, Sheff JT, Julian BA, Wyatt RJ, Suzuki H, Xie J, Chen N, Zhou X, Zhang H, Hammarström L, Viktorin A, Magnusson PKE, Shang N, Hripcsak G, Weng C, Rundek T, Elkind MSV, Oelsner EC, Barr RG, Ionita-Laza I, Novak J, Gharavi AG, Kiryluk K. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. Nat Commun. 2022 Nov 11;13(1):6859. doi: 10.1038/s41467-022-34456-6. Erratum in: Nat Commun. 2023 Feb 6;14(1):655. PMID: 36369178; PMCID: PMC9651905.
  • Rasouly HM, Balderes O, Marasa M, Fernandez H, Lipton M, Lin F, Gharavi AG, Sabatello M. The effect of genetic education on the referral of patients to genetic evaluation: Findings from a national survey of nephrologists. Genet Med. 2023 Feb 12;25(5):100814. doi: 10.1016/j.gim.2023.100814. Epub ahead of print. PMID: 36789889.
  • Thomas CP, Daloul R, Lentine KL, Gohh R, Anand PM, Rasouly HM, Sharfuddin AA, Schlondorff JS, Rodig NM, Freese ME, Garg N, Lee BK, Caliskan Y. Genetic evaluation of living kidney donor candidates: a review and recommendations for best practices. Am J Transplant. 2023 Mar 1;. doi: 10.1016/j.ajt.2023.02.020. [Epub ahead of print] Review. PubMed PMID: 36868514.
  • Kapur, S.L. Sabatello, M. People with Disability and Privacy in Precision Medicine Research: What’s at Stake? (Trends in Genetics, Jan. 2023)
  • Sabatello M., Martschenko DO, Cho MK, Brothers KB. Data sharing and community-engaged research. Science. 2022 Oct 14;378(6616):141-143. doi: 10.1126/science.abq6851. Epub 2022 Oct 13. PMID: 36227983.
  • Lemke AA, Esplin ED, Goldenberg AJ, Gonzaga-Jauregui C, Hanchard NA, Harris-Wai J, Ideozu JE, Isasi R, Landstrom AP, Prince AER, Turbitt E, Sabatello M, Schrier Vergano SA, Taylor MRG, Yu JH, Brothers KB, Garrison NA. Addressing underrepresentation in genomics research through community engagement. Am J Hum Genet. 2022 Sep 1;109(9):1563-1571. doi: 10.1016/j.ajhg.2022.08.005. PMID: 36055208; PMCID: PMC9502069.
  • McDonald, K., Schwartz, A., Sabatello, M. Eligibility Criteria in NIH-funded Clinical Trials: Can Adults with Intellectual Disability Get In? Disabil Health J. 2022 Aug 20:101368. doi: 10.1016/j.dhjo.2022.101368. Epub ahead of print. PMID: 36123292.
  • Chang JH, Mushailov V, Mohan S. Obesity and kidney transplantation. Curr Opin Organ Transplant. 2023 Apr 1;28(2):149-155. doi: 10.1097/MOT.0000000000001050. Epub 2023 Jan 31. PMID: 36752277.
  • Stevens JS, Hastie JM, Spellman J, Mittel A, Beck J, Mullin DA, Fung K, Argenziano M, Takayama H, Radhakrishnan J. Optimizing Perioperative Renal Replacement Therapy for Patients Undergoing Cardiac Surgical Procedures Requiring Cardiopulmonary Bypass. Blood Purif. 2022 Jul 25:1-7. doi: 10.1159/000525837. Epub ahead of print. PMID: 35878582.
  • Ogami T, Zimmermann E, Zhu RC, Zhao Y, Ning Y, Kurlansky P, Stevens JS, Avgerinos DV, Patel VI, Takayama H. Proximal aortic repair in dialysis patients: A national database analysis. J Thorac Cardiovasc Surg. 2023 Jan;165(1):31-39.e5. doi: 10.1016/j.jtcvs.2021.02.086. Epub 2021 Feb 27. PMID: 33812684.
  • Fakhouri F, Schwotzer N, Cabiddu G, Barratt J, Legardeur H, Garovic V, Orozco-Guillen A, Wetzels J, Daugas E, Moroni G, Noris M, Audard V, Praga M, Llurba E, Wuerzner G, Attini R, Desseauve D, Zakharova E, Luders C, Wiles K, Leone F, Jesudason S, Costedoat-Chalumeau N, Kattah A, Soto-Abraham V, Karras A, Prakash J, Lightstone L, Ronco P, Ponticelli C, Appel G, Remuzzi G, Tsatsaris V, Piccoli GB. Glomerular diseases in pregnancy: pragmatic recommendations for clinical management. Kidney Int. 2023 Feb;103(2):264-281. doi: 10.1016/j.kint.2022.10.029. Epub 2022 Dec 5. PMID: 36481180.
  • Coscia, Cohen, Dube, Hofman, Moritz, Gattis and Basu. Outcomes with Belatacept exposure during pregnancy in kidney transplant recipients: a case series. In process at Transplantation.
  • McCune K, Owen-Simon N, Dube GK, Ratner LE. The best insulin delivery is a human pancreas. Clin Transplant. 2023 Jan 26:e14920. doi: 10.1111/ctr.14920. Epub ahead of print. PMID: 36700663.
  • Dube GK, Batal I, Shah L, Robbins H, Arcasoy SM, Husain SA. BK DNAemia and native kidney polyomavirus nephropathy following lung transplantation. Am J Transplant. 2023 Feb;23(2):284-290. doi: 10.1016/j.ajt.2022.11.007. Epub 2023 Jan 12. PMID: 36804135.
  • Jennifer S Scherer, Megan E Rau, Anna Krieger, Yuhe Xia, Hua Zhong, Abraham Brody, David M Charytan, Joshua Chodosh; A Pilot Randomized Controlled Trial of Integrated Palliative Care and Nephrology Care. Kidney360. 2022 Oct 27
  • Ahram DF, Lim TY, Ke J, Jin G, Verbitsky M, Bodria M, Kil BH, Chatterjee D, Piva SE, Marasa M, Zhang JY, Cocchi E, Caridi G, Gucev Z, Lozanovski VJ, Pisani I, Izzi C, Savoldi G, Gnutti B, Capone VP, Morello W, Guarino S, Esposito P, Lambert S, Radhakrishnan J, Appel GB, Uy NS, Rao MK, Canetta PA, Bomback AS, Nestor JG, Hays T, Cohen DJ, Finale Na C, van Wijk JAE, La Scola C, Baraldi O, Tondolo F, Di Renzo D, Jamry-Dziurla A, Pezzutto A, Manca V, Mitrotti A, Santoro D, Conti G, Martino M, Giordano M, Gesualdo L, Zibar L, Masnata G, Bonomini M, Alberti D, La Manna G, Caliskan Y, Ranghino A, Marzuillo P, Kiryluk K, Krzemień G, Miklaszewska M, Lin F, Montini G, Scolari F, Fiaccadori E, Arapović A, Saraga M, McKiernan J, Alam S, Zaniew M, Szczepańska M, Szmigielska A, Sikora P, Drożdż D, Mizerska-Wasiak M, Mane S, Lifton RP, Tasic V, Latos-Bielenska A, Gharavi AG, Ghiggeri GM, Materna-Kiryluk A, Westland R, Sanna-Cherchi S. Rare Single Nucleotide and Copy Number Variants and the Etiology of Congenital Obstructive Uropathy: Implications for Genetic Diagnosis. J Am Soc Nephrol. 2023 Mar 30. doi: 10.1681/ASN.0000000000000132. Epub ahead of print. PMID: 36995132.
  • Canetta P. Right Heart, Wronged Kidneys. Clin J Am Soc Nephrol. 2023 Mar 29. doi: 10.2215/CJN.0000000000000154. Epub ahead of print. PMID: 36988331.
  • Kallash M, Wang Y, Smith A, Trachtman H, Gbadegesin R, Nester C, Canetta P, Wang C, Hunley TE, Sperati CJ, Selewski D, Ayoub I, Srivastava T, Mottl AK, Kopp J, Gillespie B, Robinson B, Chen D, Steinke J, Twombley K, Reidy K, Mucha K, Greenbaum LA, Blazius B, Helmuth M, Yonatan P, Parekh RS, Hogan S, Royal V, D’Agati V, Chishti A, Falk R, Gharavi A, Holzman L, Klein J, Smoyer W, Kretzler M, Gipson D, Kidd JM; CureGN*. Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes. Clin J Am Soc Nephrol. 2023 Mar 1;18(3):344-355. doi: 10.2215/CJN.0000000000000069. Epub 2023 Feb 8. PMID: 36763813.
  • Krissberg JR, O’Shaughnessy MM, Smith AR, Helmuth ME, Almaani S, Aviles DH, Brathwaite KE, Cai Y, Cattran D, Gbadegesin R, Glenn DA, Greenbaum LA, Iragorri S, Jain K, Khalid M, Kidd J, Kopp J, Lafayette R, Lane JC, Lugani F, Nestor JG, Parekh RS, Reidy K, Selewski DT, Sethna CB, Sperati CJ, Tuttle K, Twombley K, Vasylyeva TL, Weaver DJ Jr, Wenderfer SE, Gibson K; CureGN Consortium. Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease. Am J Kidney Dis. 2023 Mar;81(3):318-328.e1. doi: 10.1053/j.ajkd.2022.08.010. Epub 2022 Oct 1. PMID: 36191724; PMCID: PMC9974571.
  • Chen DP, Helmuth ME, Smith AR, Canetta PA, Ayoub I, Mucha K, Kallash M, Kopp JB, Gbadegesin R, Gillespie BW, Greenbaum LA, Parekh RS, Hunley TE, Sperati CJ, Selewski DT, Kidd J, Chishti A, Reidy K, Mottl AK, Gipson DS, Srivastava T, Twombley KE; CureGN Consortium. Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network. Am J Kidney Dis. 2023 Jan 3:S0272-6386(23)00002-1. doi: 10.1053/j.ajkd.2022.11.012. Epub ahead of print. PMID: 36608921.
  • Ravipati P, Freese RL, Royal V, Bu L, Canetta P, Gipson D, Kallash M, Kiryluk K, Nast C, Reich HN, Rheault MN, Saha M, Nachman PH; CureGN Consortium. Clinicopathologic Significance of Predominant Lambda Light Chain Deposition in IgA Nephropathy. Kidney Int Rep. 2022 Aug 17;7(11):2462-2473. doi: 10.1016/j.ekir.2022.08.003. PMID: 36531879; PMCID: PMC9751582.
  • Canetta P. Disentangling a Case of Glomerulonephritis with Fibrils. Clin J Am Soc Nephrol. 2022 Jul;17(7):1070-1072. doi: 10.2215/CJN.00630122. Epub 2022 Jun 2. PMID: 35654563; PMCID: PMC9269629.
  • Rosen RJ, Stevens JS, Canetta PA, Siddall E. Polyuria due to Pressure Natriuresis in Venoarterial Extracorporeal Membrane Oxygenation. ASAIO J. 2022 Jul 1;68(7):e124-e127. doi: 10.1097/MAT.0000000000001594. Epub 2022 Sep 28. PMID: 34593678.