Division of Nephrology

Division Newsletter

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Message from the Chief

Dear Division Members,

I am pleased to announce the launch of our new division newsletter, which will be a quarterly publication dedicated to sharing updates, insights, and news from our division with all members.

These are exciting times in Nephrology, with the advent of new diagnostic tools and novel therapies. As we continue to grow, it is important to stay connected and informed about how our division is contributing to these exciting developments within our field. The newsletter will serve as a platform to showcase the latest research and discoveries, new clinical programs, recent accomplishments of our members and provide resources and opportunities to enhance our professional growth and development.

We are committed to ensuring that the newsletter is engaging, informative, and reflective of the diverse interests and perspectives of our members. In future editions, we will have a spotlights dedicated to specific faculty members, fellows or administrators, and will get updates on graduates of our program.

 

Ali Gharavi, MD
Jay Meltzer Professor of Nephrology and Hypertension
Interim Chair, Department of Medicine
Chief, Division of Nephrology

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Faculty Spotlight: Dr. Sumit Mohan

Awards & Recognitions

  • Promoted to medical director of kidney transplant program
  • Dec 2022: Best of AJKD for article “ Impact of Extending Eligibility for Reinstatement of Waiting Time After Early Allograft Failure: A Decision Analysis.”
  • Oct 2022: Best of ASN Publications for the article “Declined offers for deceased donor kidneys are not an independent reflection of organ quality”
  • Jul 2023 – Jun 2024: Co-Chair, American Society of Transplantation Research Network Review Committee
  • Jul 2022 – Jun 2024: Chair, Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) Data Advisory Committee

Grants

  • Sep 2022 – May 2026: Towards rapid measurement of antibiotics in critical care setting NIBIB – R01 EB032910. Role: MPI (Stojanovic/Mohan/Lin/Cremer)

Oral Presentations

  • April 2023: Reducing Kidney discards and improving utilization of marginal organs, NKF SCM 2023.
  • Oct 2022: Challenges in access to Kidney Transplantation in the United States, Division of Special Populations, Center for Medicare and Medicaid Innovation (CMMI)

Publications

1.        *Schold JD, Huml AM, Husain SA, Poggio ED, Buchalter RB, Lopez R, Kaplan B, Mohan S. Deceased Donor Kidneys from Higher Distressed Communities are Significantly Less Likely to be Utilized for Transplantation. Am J Transplant. 2023 Mar 29. Epub ahead of print. PMID: 37001643.2.        Mohan S, Yu M, King Kl, Husain SA. Increasing discards as an unintended consequence of recent changes in kidney allocation policy. Kidney Int Rep. Accepted3.        McCulloh I, Stewart D, Kiernan K, Yazicioglu F, Patsolic H, Zinner C, Mohan S, Cartwright L. An experiment on the impact of predictive analytics on kidney offer acceptance decisions. Am J Transplant. 2023 Mar 21:S1600-6135(23)00353-2. Epub ahead of print. PMID: 36958629.4.        Snyder JJ, Schaffhausen CR, Hart A, Axelrod DA, Dils D, Formica RN Jr, Gaber AO, Hunt HF, Jones J, Mohan S, Patzer RE, Pinney SP, Ratner LE, Slaker D, Stewart D, Stewart ZA, Van Slyck S, Kasiske BL, Hirose R, Israni AK. Stakeholders’ Perspectives on Transplant Metrics: The 2022 Scientific Registry of Transplant Recipients’ Consensus Conference. Am J Transplant. 2023 Mar 21:S1600-6135(23)00355-6. Epub ahead of print. PMID: 36958628. 5.        King KL, Yu M, Husain SA, Patzer RE, Sandra V, Reese PP, Schold JD, Mohan S. Contribution of Estimates of Glomerular Filtration to the Extensive Disparities in Preemptive Listing for Kidney Transplant. Kidney Int Rep. 2022 Dec 30;8(3):442-454. doi: 10.1016/j.ekir.2022.12.021. PMID: 36938099; PMCID: PMC10014377 6.     Reese PP, Doshi MD, Hall IE, Besharatian B, Bromberg JS, Thiessen-Philbrook H, Jia Y, Kamoun M, Mansour SG, Akalin E, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort. Am J Kidney Dis. 2023 Feb;81(2):222-231.e1. Epub 2022 Oct 1. PMID: 36191727.7.     *Puttarajappa CM, Hariharan S, Zhang X, Tevar A, Mehta R, Gunabushanam V, Sood P, Hoffman W, Mohan S. Early Effect of the Circular Model of Kidney Allocation in the United States. J Am Soc Nephrol. 2023 Jan 1;34(1):ASN.2022040471. Epub 2022 Oct 27. PMID: 363025998.    *Schold JD, Nordyke RJ, Wu Z, Corvino F, Wang W, Mohan S. Clinical Events and Renal Function in the First Year Predict Long-Term Kidney Transplant Survival. Kidney360. 2022 Jan 25;3(4):714-727. PMID: 357216189.     *Li MT, Ramakrishnan A, Yu M, Daniel E, Sandra V, Sanichar N, King KL, Stevens JS, Husain SA, Mohan S. Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis. Transplant Direct. 2023 Jan 12;9(2):e1433. PMID: 36700066.10.    Liu RX, Koyawala N, Thiessen-Philbrook HR, Doshi MD, Reese PP, Hall IE, Mohan S, Parikh CR. Untargeted metabolomics of perfusate and their association with hypothermic machine perfusion and allograft failure. Kidney Int. 2022 Dec 20:S0085-2538(22)01038-9. Epub ahead of print. PMID: 36549364.10.     *Husain SA, King KL, Cron DC, Lentine KL, Adler JT, Mohan S. Influence of organ quality on the observed association between deceased donor kidney procurement biopsy findings and graft survival. Am J Transplant. 2022 Dec;22(12):2842-2854. Epub 2022 Aug 25. PMID: 35946600.11.    Patzer RE, Di M, Zhang R, McPherson L, DuBay DA, Ellis M, Wolf J, Jones H, Zayas C, Mulloy L, Reeves-Daniel A, Mohan S, Perez AC, Trivedi AN, Pastan SO; Southeastern Kidney Transplant Coalition. Referral and Evaluation for Kidney Transplantation Following Implementation of the 2014 National Kidney Allocation System. Am J Kidney Dis. 2022 Dec;80(6):707-717. Epub 2022 Mar 14. PMID: 35301050.12.     *Husain SA, Stevens JS, King KL, Robbins-Juarez SY, Cohen M, Lyashchenko AK, Cremers S, Mohan S. Timed Creatinine Clearance and Measured Glomerular Filtration Rate in Living Kidney Donors. Kidney Med. 2022 Nov 17;5(1):100572. PMID: 36713309.13.     Geetha D, Kronbichler A, Rutter M, Bajpai D, Menez S, Weissenbacher A, Anand S, Lin E, Carlson N, Sozio S, Fowler K, Bignall R, Ducharlet K, Tannor EK, Wijewickrama E, Hafidz MIA, Tesar V, Hoover R, Crews D, Varnell C, Danziger-Isakov L, Jha V, Mohan S, Parikh C, Luyckx V. Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions. Nat Rev Nephrol. 2022 Nov;18(11):724-737. Epub 2022 Aug 24. PMID: 36002770.14.    Pinsino A, Fabbri M, Braghieri L, Bohn B, Gaudig AJ, Kim A, Takeda K, Naka Y, Sayer GT, Uriel N, Demmer RT, Faillace RT, Husain SA, Mohan S, Colombo PC, Yuzefpolskaya M. The difference between cystatin C- and creatinine-based assessment of kidney function in acute heart failure. ESC Heart Fail. 2022 Oct;9(5):3139-3148. Epub 2022 Jun 27. PMID: 35762103.15.    *Husain SA, King KL, Owen-Simon NL, Fernandez HE, Ratner LE, Mohan S. Access to kidney transplantation among pediatric candidates with prior solid organ transplants in the United States. Pediatr Transplant. 2022 Sep;26(6):e14303. Epub 2022 May 26. PMID: 35615911.16.     *Yu K, Husain SA, Stevens Js, Parikh CR, Mohan S. Kidney nonprocurement in deceased donors with acute kidney injury. Clin Transplant. 2022 Aug 4:e14788. PMID 3592434517.    *Schold JD, Huml AM, Poggio ED, Reese PP, Mohan S. A tool for decision-making in kidney transplant candidates with poor prognosis to receive deceased donor transplantation in the United States. Kidney Int. 2022 Sep;102(3):640-651. Epub 2022 Jun 26. PMID: 35760150.
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Fellow's Corner

Dr. Benjamin Wooden publishes in CJASN

Dr. Benjamin Wooden published an article about 'The Role of Anti-B Cell Activating Factor Therapy for Treating Lupus Nephritis' with Dr. Radhakrishnan. CJASN 17: 1583–1585, 2022. doi: https://doi.org/10.2215/CJN.11340922.

Dr. Anna Krieger Publishes in kidney360

Dr. Anna Krieger published an article titled 'A Pilot Randomized Controlled Trial of Integrated Palliative Care and Nephrology Care.' Kidney360. 2022 Aug 12;3(10):1720-1729. doi: 10.34067/KID.0000352022.

Congratulations to Dr. soumya rajendren!

Dr. Soumya Rajendren will be joining the Division of Nephrology at New York University!

Congratulations to Dr. Mark Elliot!

Dr. Mark Elliott, our kidney precision medicine fellow, is taking a position as Clinical Associate Professor at the University of British Columbia where he will develop a kidney precision program.

Congratulations to Dr. Anna Krieger!

Dr. Anna Krieger tied the knot with her partner on 9/3/2022.

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Notable Publications

Structures of LRP2 reveal a molecular machine for endocytosis

Structures of full-length native mouse LRP2 reveal that it is a homodimer that undergoes dramatic pH-dependent structural transitions that renders it ligand-receptive at the cell surface and ligand-shedding in endosomes. Beenken et al., 2023, Cell 186, 821–836

Clinical and Genetic Characteristics of CKD Patients with High-Risk APOL1 Genotypes

In this genetically matched cohort, high-risk APOL1 genotypes were associated with an increased risk of kidney failure and eGFR decline rate, with a graded risk between specific high-risk genotypes and a lower rate of monogenic kidney disease. Rare missense variants in the inflammasome pathway may act as genetic modifiers of APOL1 effect on kidney disease. Elliot et al., J Am Soc Nephrol. 2023 Feb 9.

Comprehensive Associations between Acidosis and the Skeleton in Patients with Kidney Disease

Metabolic acidosis is associated with multiple impairments in bone quality. Future work should examine whether correction of acidosis improves bone quality and strength in patients with CKD. Levy et al., J Am Soc Nehprology. April 2023

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Notable Presentations

Dr. Ali Gharavi delivered the Brenner/Dirks Endowed Lecture on "Genetics of IgA Nephropathy" at the World Congress of Nephrology in Bangkok, Thailand.

Dr. Maya Sabatello delivered presentations titled: "Ableism and (Dis)Trust: Disability Ethics and Inclusion in Precision Medicine Research" at Oxford University on Feb. 21, 2023 & "Data Sharing and Community Engaged Research (CEnR): An Unpreventable Collision?" at NIH/NIEHS Seminar on March 9, 2023.

Dr. Sindhuri Prakash presented on "Thrombophilia And The Vascular Access" at ASDIN's 19th annual scientific meeting.

Presentations/CME Events at NKF Spring Clinical Meeting 2023 in Austin, TX

  • Dr. Ali Gharavi: Genetics in Nephrology
  • Dr. Jai Radhakrishnan: Late breaking abstract: Rapid and Sustained Proteinuria Reduction With Sparsentan in Immunoglobulin A Nephropathy (IgAN): PROTECT Study Interim Result
  • Dr. Sumit Mohan: Reducing Kidney Discards and Improving Utilization of Marginal Organs
  • Dr. Shayan Shirazian: Identifying the Patient, Making a Diagnosis and Selecting Treatments: Patient Challenges in CKD-aP

Oral & Poster Presentation at American Transplant Congress 2023

Oral presentations: 

  • Kristen King: “List Diving” to Allocate Kidneys to Lower Waitlist Priority Candidates.
  • Brendan Emmons (medical student): Are Normal Kidneys Histologically Normal?: Prevalence Of Abnormal Implantation Biopsy Findings In Living Donor Kidneys.
  • Sohil Khanna (medical student): Cold Ischemia Time (CIT), Pumping, and Delayed Graft Function (DGF) in Deceased Donor Kidney (DDK) Transplant: A Paired Kidney Analysis.
  • Miko Yu: Discrepancies in Reported Outcomes Between National Kidney Transplant Data Registries in The United States.
  • Ali Husain: Increasing Use of Kidneys in Multi-organ Transplants.

Posters 

  • Dr. Vladmir Mushailov: Frequency and Outcomes of BK Viremia after Simultaneous Heart Kidney Transplant: A Single Center Experience.
  • Dr. Euclid St. Hill: Incidence and Impact of BK Viremia in Simultaneous Liver-Kidney Transplant Recipients.
  • Miko Yu: Change in Organ Offer Volume and Bypass Filter Settings Under New Kidney Allocation System. American Transplant Congress. June 2023.
  • Brendan Emmons (medical student): Presence of Retained Renal Cysts Does Not Impact Kidney Function Recovery After Living Kidney Donation.

Other Notable Presentations and Lectures

  • Dr. Maya Sabatello: NHGRI, Disabling Structural Ableism, at NHGRI Symposium: Irreducible Subjects: Disability and Genomics in the Past, Present and Future, (Oct. 6-7, 2022)
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Notable Grants Since July, 2022

Dr. Thomas Nickolas

1. R01DK134101 – Precision medicine approaches to renal osteodystrophy

2. R01FD007629 – Advancing Product Development for Hypoparathyroidism: A Prospective Natural History Study of the Clinical Outcomes and Regulation of Disordered Mineral Metabolism

3. R56DK127986 – Renal Osteodystrophy Precision Medicine Project

4. R01DK131811 – Bone In CKD Alkali Response Pilot Trial (BICARb Pilot Trial)

Dr. Sumit Mohan

1. Sep 2022 – May 2026: Towards rapid measurement of antibiotics in critical care setting NIBIB – R01 EB032910. Role: MPI (Stojanovic/Mohan/Lin/Cremer)

Dr. Maya Sabatello

1. R01 HD108701-01, K. McDonald & M. Sabatello, MPIs 07/2022-02/2027 NICHD & NHGRI Including Adults with Intellectual Disability in Precision Medicine Research – Project ENGAGE

2. R01HG010868-04S1, M. Sabatello (PI) 07/2022-06/2023 NHGRI Blind/Disability and Intersectional Biases in E-Health Records (EHRs) of Diabetes Patients: Building a Dialogue on Equity of AI/ML Models in Clinical Care

Dr. Hila Rasouly

1. K01 award: Advancing equitable implementation of genomic medicine in nephrology)

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CRC Nephrology News

All of Us Research Program

AllofUs Research Program is an essential part of the Nephrology Division clinical research portfolio. The Program is a momentous effort to advance individualized prevention, treatment, and care for people of all backgrounds. People ages 18 and older, regardless of health status, can enroll. The overall aim is to enroll 1 million or more volunteers and oversample communities that have been underrepresented in research to make the program the largest, most diverse resource of its kind. Dr. Gharavi is the Principal Investigator for the NYC AllofUs Consortium (NYCC). Maria Morban, CRC, leads All of Us recruitment in the Division. Total enrollments in NYCC is 31, 402 (the goal is to enroll 93,000). 15, 651 participants are enrolled at Columbia, including 668 from Nephrology. In July, Maria enrolled 13 participants and was able to follow up on 9 previously enrolled.

Please, refer your patients to this study,. Feel free to email Maria at mm4345@cumc.columbia.edu if you have any questions.

IgAN Walk 6.11.23

On June 11th members of Dr. Kiryluk’s and Dr. Gharavi’s labs went to South New Jersey to participate in the IgAN annual walk. Special “thank you” goes to German Varela and Maayan Sofer, who prepared all the supplies. We recruited 21 people, including transplant patients and many family members. It was such a pleasure to reconnect with our former recruits and their family members. Sarath Krishna Murthy, the CPMG Director of Bioinformatics, took a part in the 5K run, and did very well! Nick Steers was in charge of answering science-related questions, and the participants kept him busy all the time!
 
Thank you to everyone who took a part in it: 

(German Varela, Estephany Disla, Maayan Sofer, Maria Morban, Vanna Nicasio, Sharvari Pathak, Jenna Simpson, Rachel Mufson, Nikita Toma, Kelsey Stevens, Nick Steers, Sarath Krishna Murth, Vita Kolupaeva)

 

eMERGE IV Update

eMERGE IV (Electronic Medical Records and Genomics Phase IV) Study (Dr. Krzysztof Kiryluk is one of the Principal Investigators) has now approached 50% target with nearly 1,200 participants enrolled; first genomic risk reports are now being returned to the participants and their physicians. It is an amazing milestone! Congratulations! German Varela and Estefhany Disla, CRCs, enroll patients not only in Nephrology, but all over the campus, even traveling to the Tarrytown clinic. The recruitment will continue over the next 12 months, so it’s not too late to participate or refer your patients for this exciting study!