Genetics of the Development of the Urinary Tract (DONUT) Enrollment:

Inclusion Criteria:

• CAKUT: all patients with ultrasound documented structural anomaly(ies) within the kidney and urinary tract, including but not limited to hydronephrosis, renal dysplasia/hypoplasia, solitary kidney, posterior urethral valves, ureteral anomalies, ureteropelvic junction obstruction and vesicoureteral reflux. All ages, all ethnicities and all stages of CKD are eligible. Prenatal diagnosis of CAKUT will need postnatal diagnosis for study enrollment.  

Exclusion Criteria:

• None – we aim to include patients from non-speaking families (appropriate informed consent in native language will be given to families) single parents, and adopted children.      

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) Research and Enrollment:

Inclusion Criteria:

• Clinically diagnosed with constitutional Disorder based on standard parameters or a family member of someone who has been diagnosed with constitutional disorder.

 • Adult Control (18 years old and above)

  Exclusion Criteria:

• None

Nephrotic Syndrome Research Enrollment

Inclusion Criteria: Patients with Nephrotic Syndrome

Exclusion Criteria:

• None

rFSGS Enrollment: 

Inclusion criteria:

• Clinically diagnosed patientswith Idiopathic Nephrotic syndrome and related conditions

• Kidney transplant patients with a diagnosis of recurrent FSGS
• Family members of enrolled patients
• Pediatric and Adult Controls

Exclusion criteria:

• Patients with other glomerular diseases or secondary forms of NS/FS